KE and EE genotypes of ICAM-1 gene K469E polymorphism is associated with severe preeclampsia.

ABSTRACT:

Background

Preeclampsia (PE) is one of the most important complications of pregnancy that is associated with significant mortality and morbidity in mother and fetus. Since the etiologic factors in its development are still unclear, we aimed to examine the intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism in preeclamptic and control healthy women.

Materials and methods

Genetic polymorphism was analyzed in 192 PE and 186 healthy control women. PCR-RFLP method was used to identify K469E polymorphism.

Results

The frequency of KK, KE, and EE genotypes of ICAM-1 gene was not different between PE patients and healthy pregnant women. Whereas, the frequency of KE and EE genotypes was significantly higher in severe PE than mild PE women and control group, and t

SUBMITTER: Tabatabai E 

PROVIDER: S-EPMC3925614 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature