Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia.

ABSTRACT:

Importance

Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinical measures of grammatical comprehension are unavailable.

Objective

To develop a measure of grammatical comprehension and examine this comparatively in PPA variants and behavioural-variant frontotemporal degeneration (bvFTD) and to assess the neuroanatomic basis for these deficits with volumetric grey matter atrophy and whole-brain fractional anisotropy (FA) in white matter tracts.

Design

Case-control study.

Setting

Academic medical centre.

Participants

39 patients with variants of PPA (naPPA=12, lvPPA=15 and svPPA=12), 27 bvFTD patients without aphasia and 12 healthy con

SUBMITTER: Charles D 

PROVIDER: S-EPMC3925677 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature