Tissue specificity in the nuclear envelope supports its functional complexity.

ABSTRACT: Nuclear envelope links to inherited disease gave the conundrum of how mutations in near-ubiquitous proteins can yield many distinct pathologies, each focused in different tissues. One conundrum-resolving hypothesis is that tissue-specific partner proteins mediate these pathologies. Such partner proteins may have now been identified with recent proteome studies determining nuclear envelope composition in different tissues. These studies revealed that the majority of the total nuclear envelope proteins are tissue restricted in their expression. Moreover, functions have been found for a number these tissue-restricted nuclear envelope proteins that fit with mechanisms proposed to explain how the nuclear envelope could mediate disease, including defects in mechanical stability, cell cycle regul

SUBMITTER: de Las Heras JI 

PROVIDER: S-EPMC3925691 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature