Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism.

ABSTRACT:

Background

Maternal obesity (MO) impairs maternal and offspring health. Mechanisms and interventions to prevent adverse maternal and offspring outcomes need to be determined. Human studies are confounded by socio-economic status providing the rationale for controlled animal data on effects of maternal exercise (MEx) intervention on maternal (F0) and offspring (F1) outcomes in MO.

Hypothesis

MO produces metabolic and endocrine dysfunction, increases maternal and offspring glucocorticoid exposure, oxidative stress and adverse offspring outcomes by postnatal day (PND) 36. MEx in part prevents these outcomes.

Methods

F0 female rats ate either control or obesogenic diet from weaning through lactation. Half of each group wheel ran (from day 90 of life through pregnancy begi

SUBMITTER: Vega CC 

PROVIDER: S-EPMC3925765 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature