Clinical proteomics identifies potential biomarkers in Helicobacter pylori for gastrointestinal diseases.

ABSTRACT: The development of gastrointestinal diseases has been found to be associated with Helicobacter pylori (H. pylori) infection and various biochemical stresses in stomach and intestine. These stresses, such as oxidative, osmotic and acid stresses, may bring about bi-directional effects on both hosts and H. pylori, leading to changes of protein expression in their proteomes. Therefore, proteins differentially expressed in H. pylori under various stresses not only reflect gastrointestinal environment but also provide useful biomarkers for disease diagnosis and prognosis. In this regard, proteomic technology is an ideal tool to identify potential biomarkers as it can systematically monitor proteins and protein variation on a large scale of cell's translational landscape, permitting in-depth anal

SUBMITTER: Huang CH 

PROVIDER: S-EPMC3925861 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature