Regulating specific growth factor signaling using immobilized branched ligands.

ABSTRACT: VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.

SUBMITTER: Toepke MW 

PROVIDER: S-EPMC3925890 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature