Generation of human ER chaperone BiP in yeast Saccharomyces cerevisiae.

ABSTRACT:

Background

Human BiP is traditionally regarded as a major endoplasmic reticulum (ER) chaperone performing a number of well-described functions in the ER. In recent years it was well established that this molecule can also be located in other cell organelles and compartments, on the cell surface or be secreted. Also novel functions were assigned to this protein. Importantly, BiP protein appears to be involved in cancer and rheumatoid arthritis progression, autoimmune inflammation and tissue damage, and thus could potentially be used for therapeutic purposes. In addition, a growing body of evidence indicates BiP as a new therapeutic target for the treatment of neurodegenerative diseases. Increasing importance of this protein and its involvement in critical human diseases demands new

SUBMITTER: Ciplys E 

PROVIDER: S-EPMC3926315 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature