Has pharmacogenetics brought us closer to 'personalized medicine' for initial drug treatment of hypertension?

ABSTRACT:

Purpose of review

To describe recent advances in antihypertensive pharmacogenetics and discuss challenges related to translating this knowledge into 'personalized medicine' for the initial drug treatment of hypertension.

Recent findings

Recent studies included both prospective and retrospective analyses ranging from small clinical investigations of 42 participants to large, multicenter, randomized, outcome-based clinical trials of nearly 40 000 individuals. Treatment with drugs from five classes of antihypertensives was evaluated in these studies. The duration of treatment ranged from week-long follow up for blood pressure response to a decade-long follow up for clinical outcomes. In total, associations with 12 different candidate genes were assessed. These studies present t

SUBMITTER: Arnett DK 

PROVIDER: S-EPMC3926658 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature