CD11c⁺ cells primed with unrelated antigens facilitate an accelerated immune response to influenza virus in mice.

ABSTRACT: Recent evidence suggests that an individual's unique history and sequence of exposures to pathogens and antigens may dictate downstream immune responses to disparate antigens. We show that the i.n. delivery of nonreplicative virus-like particles (VLPs), which bear structural but no antigenic similarities to respiratory pathogens, acts to prime the lungs of both C56BL/6 and BALB/c mice, facilitating heightened and accelerated primary immune responses to high-dose influenza challenge, thus providing a nonpathogenic model of innate imprinting. These responses correspond closely to those observed following natural infection with the opportunistic fungus, Pneumocystis murina, and are characterized by accelerated antigen processing by DCs and alveolar macrophages, an enhanced influx of cells to

SUBMITTER: Richert LE 

PROVIDER: S-EPMC3926668 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature