The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies.

ABSTRACT:

Background

The results of previous studies assessing the association between the 5-HTTLPR polymorphism of serotonin transporter gene and irritable bowel syndrome (IBS) are inconsistent. The aim of this study was to clarify the association between the 5-HTTLPR mutation and the presence of IBS and its subtypes with a meta-analysis of 25 studies.

Methods

A thorough search for case-control studies evaluating the association between the 5-HTTLPR polymorphism of serotonin transporter gene and the presence of IBS was carried out in four electronic databases. A meta-analysis was performed in accordance with the Cochrane Handbook for systemic reviews.

Results

A total of 25 articles with 3443 IBS cases and 3359 controls were included into our meta-analysis. No significant assoc

SUBMITTER: Zhang ZF 

PROVIDER: S-EPMC3926682 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature