Relationships between inflammation, immune activation, and bone health among HIV-infected adults on stable antiretroviral therapy.

ABSTRACT:

Background

The aim was to determine the association between bone health and inflammation, T-cell activation, and monocyte activation among HIV-infected persons on stable antiretroviral therapy.

Methods

We performed a cross-sectional analysis of all the subjects enrolling in the Stopping Atherosclerosis and Treating Unhealthy bone with RosuvastatiN in HIV trial with available skeletal assessments by dual-energy x-ray absorptiometry, inflammation, and immune activation markers. Analyses used were Wilcoxon rank-sum tests, Spearman correlation coefficients, and linear regression.

Results

One hundred forty-two subjects were included: 78% men, 69% African American, median age 46.3 years, CD4 count 604 cells per microliter, and 77% with undetectable HIV-1 RNA. Twenty-three p

SUBMITTER: Erlandson KM 

PROVIDER: S-EPMC3927157 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature