Pregabalin-associated myoclonic encephalopathy without evidence of drug accumulation in a patient with acute renal failure.

ABSTRACT: Pregabalin, used for treating partial epilepsy and neuropathic pain, is usually well tolerated. Patients with impaired renal function are at risk to develop more serious adverse events. A 64-year-old woman was admitted in the Emergency Department for altered consciousness and abnormal movements. She recently started to take pregabalin (150 mg/day) for neuropathic pain. The drug was withdrawn 36 h before hospitalization following worsening of neurological symptoms. At physical examination, myoclonus was noted as main finding in the limbs and head, with encephalopathy. Laboratory investigations revealed acute renal failure with serum creatinine at 451.3 μmol/l. Urine output was preserved. After supportive care alone, myoclonus resolved after 24 h and consciousness was normal after 48 h. Rena

SUBMITTER: Courtois F 

PROVIDER: S-EPMC3927193 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature