Identification of biomarkers to assess organ quality and predict posttransplantation outcomes.

ABSTRACT:

Unlabelled

The increased disparity between organ supply and need has led to the use of extended criteria donors and donation after cardiac death donors with other comorbidities.

Methods

We have examined the preimplantation transcriptome of 112 kidney transplant recipient samples from 100 deceased-donor kidneys by microarray profiling. Subject groups were segregated based on estimated glomerular filtration rate (eGFR) at 1 month after transplantation: the GFR-high group (n=74) included patients with eGFR 45 mL/min per 1.73 m(2), whereas the GFR-low group (n=35) included patients with eGFR 45 mL/min or less per 1.73 m(2).

Results

Gene expression profiling identified higher expression of 160 probe sets (140 genes) in the GFR-low group, whereas expression of 37 probe sets

SUBMITTER: Scian MJ 

PROVIDER: S-EPMC3927314 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature