Association between an interleukin 1 receptor, type I promoter polymorphism and self-reported attentional function in women with breast cancer.

ABSTRACT: Subgroups of patients with breast cancer may be at greater risk for cytokine-induced changes in cognitive function after diagnosis and during treatment. The purposes of this study were to identify subgroups of patients with distinct trajectories of attentional function and evaluate for phenotypic and genotypic (i.e., cytokine gene polymorphisms) predictors of subgroup membership. Self-reported attentional function was evaluated in 397 patients with breast cancer using the Attentional Function Index before surgery and for six months after surgery (i.e., seven time points). Using growth mixture modeling, three attentional function latent classes were identified: High (41.6%), Moderate (25.4%), and Low-moderate (33.0%). Patients in the Low-moderate class were significantly younger than those

SUBMITTER: Merriman JD 

PROVIDER: S-EPMC3927406 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature