Postoperative sleep disturbances after zolpidem treatment in fast-track hip and knee replacement.

ABSTRACT:

Study objectives

Previous studies have demonstrated pronounced reduction of REM sleep on the first nights following major surgery which may influence pain, analgesic use, and recovery. This placebo-controlled, randomized, double-blind study set out to evaluate the effect of zolpidem on sleep architecture in an elderly population undergoing fast-track total hip and knee arthroplasty (THA/TKA) with length of stay < 3 days.

Methods

Twenty patients (≥ 60 years) undergoing THA or TKA in a standardized setup with spinal anesthesia and multimodal opioid-sparing postoperative analgesia were included. Polysomnography measures were performed for 2 nights, 1 night at home prior to surgery and on the first night after surgery, when the patient received placebo or zolpidem 10 mg. Analges

SUBMITTER: Krenk L 

PROVIDER: S-EPMC3927439 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature