Reassessing domain architecture evolution of metazoan proteins: the contribution of different evolutionary mechanisms.

ABSTRACT: In the accompanying papers we have shown that sequence errors of public databases and confusion of paralogs and epaktologs (proteins that are related only through the independent acquisition of the same domain types) significantly distort the picture that emerges from comparison of the domain architecture (DA) of multidomain Metazoan proteins since they introduce a strong bias in favor of terminal over internal DA change. The issue of whether terminal or internal DA changes occur with greater probability has very important implications for the DA evolution of multidomain proteins since gene fusion can add domains only at terminal positions, whereas domain-shuffling is capable of inserting domains both at internal and terminal positions. As a corollary, overestimation of terminal DA changes

SUBMITTER: Nagy A 

PROVIDER: S-EPMC3927616 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature