Potential for intranasal drug delivery to alter cerebrospinal fluid outflow via the nasal turbinate lymphatics.

ABSTRACT:

Background

Cerebrospinal fluid absorption (CSF) at the cribriform plate is mediated by direct extracranial connections to the lymphatic system. Given the accessibility of these pharmacologically responsive vessels we hypothesized that the rate of CSF outflow can be modulated via the intranasal delivery of drugs known to affect lymphatic contractile activity.

Findings

Fluid was infused into the lateral ventricle of anesthetized sheep and inflow rate and CSF pressure measured during intranasal administration of pharmacological agents. CSF absorption was calculated at steady-state CSF pressures. The ability of a pharmacological agent to alter CSF absorption was related to the steady-state intracranial pressure (ICP), the concentration and the class of pharmacological agent deli

SUBMITTER: Kim H 

PROVIDER: S-EPMC3927830 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature