Effect of normal aging versus hypertension, abnormal body mass index, and diabetes mellitus on white matter hyperintensity volume.

ABSTRACT:

Background and purpose

The natural history of white matter hyperintensity (WMH) progression resulting from normal aging versus comorbid vascular insults remains unclear. Therefore we investigated age-related differences in WMH volumes among a group with comorbid hypertension, abnormal body mass index, and diabetes mellitus to a normal aging group drawn from the same population lacking any of these comorbidities.

Methods

WMH volumes were acquired using 3T MRI for 2011 Dallas Heart Study participants. The slope of the WMH versus age regression was compared between normal and comorbidity groups<50 and ≥50 years of age where a change in slope was demonstrated.

Results

Aging was linearly associated with greater log WMH volume for both normal (P=0.02) and comorbidity (P<0.0

SUBMITTER: King KS 

PROVIDER: S-EPMC3928033 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature