Transient mild hyperthermia induces E-selectin mediated localization of mesoporous silicon vectors in solid tumors.

ABSTRACT:

Background

Hyperthermia treatment has been explored as a strategy to overcome biological barriers that hinder effective drug delivery in solid tumors. Most studies have used mild hyperthermia treatment (MHT) to target the delivery of thermo-sensitive liposomes carriers. Others have studied its application to permeabilize tumor vessels and improve tumor interstitial transport. However, the role of MHT in altering tumor vessel interfacial and adhesion properties and its relationship to improved delivery has not been established. In the present study, we evaluated effects of MHT treatment on tumor vessel flow dynamics and expression of adhesion molecules and assessed enhancement in particle localization using mesoporous silicon vectors (MSVs). We also determined the optimal time windo

SUBMITTER: Kirui DK 

PROVIDER: S-EPMC3928046 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature