Postembryonic lineages of the Drosophila brain: II. Identification of lineage projection patterns based on MARCM clones.

ABSTRACT: The Drosophila central brain is largely composed of lineages, units of sibling neurons derived from a single progenitor cell or neuroblast. During the early embryonic period, neuroblasts generate the primary neurons that constitute the larval brain. Neuroblasts reactivate in the larva, adding to their lineages a large number of secondary neurons which, according to previous studies in which selected lineages were labeled by stably expressed markers, differentiate during metamorphosis, sending terminal axonal and dendritic branches into defined volumes of the brain neuropil. We call the overall projection pattern of neurons forming a given lineage the "projection envelope" of that lineage. By inducing MARCM clones at the early larval stage, we labeled the secondary progeny of each neuroblas

SUBMITTER: Wong DC 

PROVIDER: S-EPMC3928077 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature