Predictive value of updating Framingham risk scores with novel risk markers in the U.S. general population.

ABSTRACT:

Background

According to population-based cohort studies CT coronary calcium score (CTCS), carotid intima-media thickness (cIMT), high-sensitivity C- reactive protein (CRP), and ankle-brachial index (ABI) are promising novel risk markers for improving cardiovascular risk assessment. Their impact in the U.S. general population is however uncertain. Our aim was to estimate the predictive value of four novel cardiovascular risk markers for the U.S. general population.

Methods and findings

Risk profiles, CRP and ABI data of 3,736 asymptomatic subjects aged 40 or older from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 exam were used along with predicted CTCS and cIMT values. For each subject, we calculated 10-year cardiovascular risks with and without ea

SUBMITTER: Ferket BS 

PROVIDER: S-EPMC3928195 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature