Job strain and the risk of inflammatory bowel diseases: individual-participant meta-analysis of 95,000 men and women.

ABSTRACT:

Background and aims

Many clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn's disease and ulcerative colitis using individual-level data from 95,000 European adults.

Methods

We conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn's disea

SUBMITTER: Heikkila K 

PROVIDER: S-EPMC3928274 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature