Lack of association between mannose binding lectin and antibody responses after acellular pertussis vaccinations.

ABSTRACT:

Background

Mannose-binding lectin (MBL) is one of the key molecules in innate immunity and its role in human vaccine responses is poorly known. This study aimed to investigate the possible association of MBL polymorphisms with antibody production after primary and booster vaccinations with acellular pertussis vaccines in infants and adolescents.

Methodology/principal findings

Five hundred and sixty eight subjects were included in this study. In the adolescent cohort 355 subjects received a dose of diphtheria and tetanus toxoids and acellular pertussis (dTpa) vaccine ten years previously. Follow-up was performed at 3, 5 and 10 years. Infant cohort consisted of 213 subjects, who had received three primary doses of DTaP vaccine at 3, 5, and 12 months of age according to Finnish

SUBMITTER: Grondahl-Yli-Hannuksela K 

PROVIDER: S-EPMC3928324 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature