Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells.

ABSTRACT: Recent studies show that naïve T cells bearing identical T cell receptors experience heterogeneous differentiation and clonal expansion processes. The factors controlling this outcome are not well characterized, and their contributions to immune cell dynamics are similarly poorly understood. In this study, we develop a computational model to elaborate mechanisms occurring within and between two important physiological compartments, lymph nodes and blood, to determine how immune cell dynamics are controlled. Our multi-organ (multi-compartment) model integrates cellular and tissue level events and allows us to examine the heterogeneous differentiation of individual precursor cognate naïve T cells to generate both effector and memory T lymphocytes. Using this model, we simulate a hypothetical

SUBMITTER: Gong C 

PROVIDER: S-EPMC3928592 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature