Alcohol consumption and cognitive decline in early old age.

ABSTRACT:

Objective

To examine the association between alcohol consumption in midlife and subsequent cognitive decline.

Methods

Data are from 5,054 men and 2,099 women from the Whitehall II cohort study with a mean age of 56 years (range 44-69 years) at first cognitive assessment. Alcohol consumption was assessed 3 times in the 10 years preceding the first cognitive assessment (1997-1999). Cognitive tests were repeated in 2002-2004 and 2007-2009. The cognitive test battery included 4 tests assessing memory and executive function; a global cognitive score summarized performances across these tests. Linear mixed models were used to assess the association between alcohol consumption and cognitive decline, expressed as z scores (mean = 0, SD = 1).

Results

In men, there were no diff

SUBMITTER: Sabia S 

PROVIDER: S-EPMC3929201 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature