Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study.

ABSTRACT:

Objective

To describe the frequency of mild cognitive impairment (MCI) in Parkinson disease (PD) in a cohort of newly diagnosed incident PD cases and the associations with a panel of biomarkers.

Methods

Between June 2009 and December 2011, 219 subjects with PD and 99 age-matched controls participated in clinical and neuropsychological assessments as part of a longitudinal observational study. Consenting individuals underwent structural MRI, lumbar puncture, and genotyping for common variants of COMT, MAPT, SNCA, BuChE, EGF, and APOE. PD-MCI was defined with reference to the new Movement Disorder Society criteria.

Results

The frequency of PD-MCI was 42.5% using level 2 criteria at 1.5 SDs below normative values. Memory impairment was the most common domain affected, wi

SUBMITTER: Yarnall AJ 

PROVIDER: S-EPMC3929202 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature