Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment.

ABSTRACT: Mounting evidence indicates that anomalies in the inflammatory and immune response pathways are essential to tumorigenesis. However, tumor-based innate immunity initiated by transformed breast epithelia tissues has received much less attention. This review summarizes published reports on the role of the toll-like receptor signaling pathway on breast cancer risk, disease progression, survival, and disease recurrence. Specifically, we discuss the underlying biological mechanisms that contribute to the tumorigenic and/or anti-tumorigenic properties of toll-like receptors and their associated agonists in relation to breast tumorigenesis and cancer treatment. Further, we use results from preclinical, clinical, and population-based studies as prompts for the exploration of new and more effective

SUBMITTER: Kidd LC 

PROVIDER: S-EPMC3929246 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature