The impact of genetic variants in inflammatory-related genes on prostate cancer risk among men of African Descent: a case control study.

ABSTRACT:

Purpose

Although case-control studies have evaluated the role of variant inflammatory-related loci in prostate cancer, their impact is virtually unknown among men of African descent. To address this, we evaluated the impact of inflammatory cytokine single nucleotide polymorphisms (SNPs) on prostate cancer risk for men of African descent.

Methods

Forty-four SNPs in inflammatory cytokine-associated genes were evaluated among 814 African-American and Jamaican men (279 prostate cancer cases and 535 controls) using Illumina's Golden gate genotyping system. Individual SNP effects were evaluated using logistic regression analysis.

Results

Four SNPs were modestly associated with prostate cancer after adjusting for age. In the total population, inheritance of the IL1R2 rs11886

SUBMITTER: Jones DZ 

PROVIDER: S-EPMC3929257 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature