Prior appendectomy does not protect against subsequent development of malignant or borderline mucinous ovarian neoplasms.

ABSTRACT:

Background

Due to concern that mucinous malignant or borderline ovarian neoplasms (MON) may represent metastatic deposits from appendiceal primaries, gynecologic oncologists routinely perform appendectomy in these cases. However, a multidisciplinary critique of this practice is lacking.

Methods

The New England Case-Control study database was utilized to compare the effect of prior appendectomy against known risk factors for MON. Pathology and operative reports of local cases of MON were reviewed to estimate the frequency of microscopic mucinous lesions in the appendix. Protein expression patterns among mucinous ovarian, colorectal, and appendiceal cancers were compared by immunohistochemistry.

Results

From the New England Case-Control study, 287 cases of MON were comp

SUBMITTER: Elias KM 

PROVIDER: S-EPMC3929430 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature