Enhancement of anti-tumor CD8 immunity by IgG1-mediated targeting of Fc receptors.

ABSTRACT: Dendritic cells (DCs) function as professional antigen presenting cells and are critical for linking innate immune responses to the induction of adaptive immunity. Many current cancer DC vaccine strategies rely on differentiating DCs, feeding them tumor antigens ex vivo, and infusing them into patients. Importantly, this strategy relies on prior knowledge of suitable “tumor-specific” antigens to prime an effective anti-tumor response. DCs express a variety of receptors specific for the Fc region of immunoglobulins, and antigen uptake via Fc receptors is highly efficient and facilitates antigen presentation to T cells. Therefore, we hypothesized that expression of the mouse IgG1 Fc region on the surface of tumors would enhance tumor cell uptake by DCs and other myeloid cells and promote the

SUBMITTER: Furlan SN 

PROVIDER: S-EPMC3929435 | biostudies-literature | 2014 Jan-Feb

REPOSITORIES: biostudies-literature