Meta-selective C-H functionalization using a nitrile-based directing group and cleavable Si-tether.

ABSTRACT: A nitrile-based template that enables meta-selective C-H bond functionalization was developed. The template is applicable to a range of substituted arenes and tolerates a variety of functional groups. The directing group uses a silicon atom for attachment, allowing for a facile introduction/deprotection strategy increasing the synthetic practicality of this template.

SUBMITTER: Lee S 

PROVIDER: S-EPMC3929498 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature