Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144.

ABSTRACT:

Rationale

Foam cell formation because of excessive accumulation of cholesterol by macrophages is a pathological hallmark of atherosclerosis, the major cause of morbidity and mortality in Western societies. Liver X nuclear receptors (LXRs) regulate the expression of the adenosine triphosphate-binding cassette (ABC) transporters, including adenosine triphosphate-binding cassette transporter A1 (ABCA1) and adenosine triphosphate-binding cassette transporter G1 (ABCG1). ABCA1 and ABCG1 facilitate the efflux of cholesterol from macrophages and regulate high-density lipoprotein (HDL) biogenesis. Increasing evidence supports the role of microRNA (miRNAs) in regulating cholesterol metabolism through ABC transporters.

Objective

We aimed to identify novel miRNAs that regulate choleste

SUBMITTER: Ramirez CM 

PROVIDER: S-EPMC3929583 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature