Tumor suppressor NF2/Merlin is a microtubule stabilizer.

ABSTRACT: Cancer-associated mutations in oncogene products and tumor suppressors contributing to tumor progression manifest themselves, at least in part, by deregulating microtubule-dependent cellular processes that play important roles in many cell biological pathways, including intracellular transport, cell architecture, and primary cilium and mitotic spindle organization. An essential characteristic of microtubules in the performance of these varied cell processes is their ability to continuously remodel, a phenomenon known as dynamic instability. It is therefore conceivable that part of the normal function of certain cancer-causing genes is to regulate microtubule dynamic instability. Here, we report the results of a high-resolution live-cell image-based RNA interference screen targeting a colle

SUBMITTER: Smole Z 

PROVIDER: S-EPMC3929585 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature