The relationship between BCMO1 gene variants and macular pigment optical density in persons with and without age-related macular degeneration.

ABSTRACT:

Background

Recent evidence indicates that gene variants related to carotenoid metabolism play a role in the uptake of macular pigments lutein (L) and zeaxanthin (Z). Moreover, these pigments are proposed to reduce the risk for advanced age-related macular degeneration (AMD). This study provides the initial examination of the relationship between the gene variants related to carotenoid metabolism, macular pigment optical density (MPOD) and their combined expression in healthy humans and patients with AMD.

Participants and methods

Forty-four participants were enrolled from a general population and a private practice including 20 healthy participants and 24 patients with advanced (neovascular) AMD. Participants were genotyped for the three single nucleotide polymorphisms (SNPs)

SUBMITTER: Feigl B 

PROVIDER: S-EPMC3929644 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature