The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.

ABSTRACT:

Unlabelled

Low-to-moderate levels of reactive oxygen species (ROS) govern different steps of neurogenesis via molecular pathways that have been decrypted only partially. Although it has been postulated that redox-sensitive molecules are involved in neuronal differentiation, the molecular bases for this process have not been elucidated yet. The aim of this work was therefore to study the role played by the redox-sensitive, multifunctional protein APE1/Ref-1 (APE1) in the differentiation process of human adipose tissue-derived multipotent adult stem cells (hAT-MASC) and embryonic carcinoma stem cells (EC) towards a neuronal phenotype.

Methods and results

Applying a definite protocol, hAT-MASC can adopt a neural fate. During this maturation process, differentiating cells signif

SUBMITTER: Domenis R 

PROVIDER: S-EPMC3929656 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature