Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality.

ABSTRACT:

Rationale

Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness. However, elevated levels early in acute respiratory failure have been associated with mortality. Polymorphisms in adiponectin-related genes (ADIPOQ, ADIPOR1, ADIPOR2) have been examined for relationships with obesity, insulin resistance and diabetes, cardiovascular disease, and to circulating adipokine levels, but many gaps in knowledge remain. The current study aims to assess the association between potentially functional polymorphisms in adiponectin-related genes with acute respiratory distress syndrome (ARDS) risk and mortality.

Methods

Consecutive patients with risk facto

SUBMITTER: Ahasic AM 

PROVIDER: S-EPMC3929660 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature