Application of stem cells derived from the periodontal ligament or gingival tissue sources for tendon tissue regeneration.

ABSTRACT: Tendon injuries are often associated with significant dysfunction and disability due to tendinous tissue's very limited self-repair capacity and propensity for scar formation. Dental-derived mesenchymal stem cells (MSCs) in combination with appropriate scaffold material present an alternative therapeutic option for tendon repair/regeneration that may be advantageous compared to other current treatment modalities. The MSC delivery vehicle is the principal determinant for successful implementation of MSC-mediated regenerative therapies. In the current study, a co-delivery system based on TGF-β3-loaded RGD-coupled alginate microspheres was developed for encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs). The capacity of encapsulated dental MSCs t

SUBMITTER: Moshaverinia A 

PROVIDER: S-EPMC3929697 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature