Aggregate exposure approaches for parabens in personal care products: a case assessment for children between 0 and 3 years old.

ABSTRACT: In the risk assessment of chemical substances, aggregation of exposure to a substance from different sources via different pathways is not common practice. Focusing the exposure assessment on a substance from a single source can lead to a significant underestimation of the risk. To gain more insight on how to perform an aggregate exposure assessment, we applied a deterministic (tier 1) and a person-oriented probabilistic approach (tier 2) for exposure to the four most common parabens through personal care products in children between 0 and 3 years old. Following a deterministic approach, a worst-case exposure estimate is calculated for methyl-, ethyl-, propyl- and butylparaben. As an illustration for risk assessment, Margins of Exposure (MoE) are calculated. These are 991 and 4966 for meth

SUBMITTER: Gosens I 

PROVIDER: S-EPMC3929779 | biostudies-literature | 2014 Mar-Apr

REPOSITORIES: biostudies-literature