Circulating biomarkers for detection of ovarian cancer and predicting cancer outcomes.

ABSTRACT:

Background

Securing a diagnosis of ovarian cancer and establishing means to predict outcomes to therapeutics remain formidable clinical challenges. Early diagnosis is particularly important since survival rates are markedly improved if tumour is detected early.

Methods

Comprehensive miRNA profiles were generated on presurgical plasma samples from 42 women with confirmed serous epithelial ovarian cancer, 36 women diagnosed with a benign neoplasm, and 23 comparably age-matched women with no known pelvic mass.

Results

Twenty-two miRNAs were differentially expressed between healthy controls and the ovarian cancer group (P<0.05), while a six miRNA profile subset distinguished presurgical plasma from benign and ovarian cancer patients. There were also significant difference

SUBMITTER: Shapira I 

PROVIDER: S-EPMC3929876 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature