The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction.

ABSTRACT: The human SLC6 family is composed of approximately 20 structurally related symporters (co-transporters) that use the transmembrane electrochemical gradient to actively import their substrates into cells. Approximately half of the substrates of these transporters are amino acids, with others transporting biogenic amines and/or closely related compounds, such as nutrients and compatible osmolytes. In this short review, five leaders in the field discuss a number of currently important research themes that involve SLC6 transporters, highlighting the integrative role they play across a wide spectrum of different functions. The first essay, by Gary Rudnick, describes the molecular mechanism of their coupled transport which is being progressively better understood based on new crystal structures,

SUBMITTER: Rudnick G 

PROVIDER: S-EPMC3930102 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature