In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer's disease.

ABSTRACT:

Unlabelled

Acetylcholine-esterase (AchE) inhibitors are one of the most potent drug molecules against Alzheimer's disease (AD). But, patients treated with current AchE inhibitors often experience severe side effects. Quercetin is a plant flavonoid compound which can act as AchE inhibitor and it may be a better alternative to current AchE inhibitors in terms of effectiveness with no or fewer side effects.

Aims

The aim of the study was to compare quercetin with conventional AchE inhibitors to search for a better drug candidate.

Methods and materials

Physico-chemical properties of conventional drugs and quercetin were predicted using bioinformatics tools. Molecular docking of these compounds on the active site of AchE was performed using AutoDock and comparative analysis

SUBMITTER: Islam MR 

PROVIDER: S-EPMC3930111 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature