Limited dengue virus replication in field-collected Aedes aegypti mosquitoes infected with Wolbachia.

ABSTRACT:

Introduction

Dengue is one of the most widespread mosquito-borne diseases in the world. The causative agent, dengue virus (DENV), is primarily transmitted by the mosquito Aedes aegypti, a species that has proved difficult to control using conventional methods. The discovery that A. aegypti transinfected with the wMel strain of Wolbachia showed limited DENV replication led to trial field releases of these mosquitoes in Cairns, Australia as a biocontrol strategy for the virus.

Methodology/principal findings

Field collected wMel mosquitoes that were challenged with three DENV serotypes displayed limited rates of body infection, viral replication and dissemination to the head compared to uninfected controls. Rates of dengue infection, replication and dissemination in field wMel

SUBMITTER: Frentiu FD 

PROVIDER: S-EPMC3930499 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature