Higher serum direct bilirubin levels were associated with a lower risk of incident chronic kidney disease in middle aged Korean men.

ABSTRACT:

Background

The association between serum bilirubin levels and incident chronic kidney disease (CKD) in the general population is unknown. We aimed to examine the association between serum bilirubin concentration (total, direct, and indirect) and the risk of incident CKD.

Methods and findings

Longitudinal cohort study of 12,823 Korean male workers 30 to 59 years old without CKD or proteinuria at baseline participating in medical health checkup program in a large worksite. Study participants were followed for incident CKD from 2002 through 2011. Estimated glomerular filtration rate (eGFR) was estimated by using the CKD-EPI equation. CKD was defined as eGFR <60 mL/min per 1.73 m(2). Parametric Cox models and pooled logistic regression models were used to estimate adjusted hazar

SUBMITTER: Ryu S 

PROVIDER: S-EPMC3930500 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature