Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.

ABSTRACT: Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria are able to replicate intracellularly under certain conditions, it is also clear that macrophages are capable of killing M. tuberculosis if appropriately activated. The outcome of infection is determined at least in part by the host-pathogen interaction within the macrophage; however, we lack a complete understanding of which host pathways are critical for bacterial survival and replication. To add to our understanding of the molecular processes involved in intracellular infection, we performed a chemical screen using a high-content microscopic assay to identify small molecules that restrict mycobacterial growth in macrophages by targe

SUBMITTER: Stanley SA 

PROVIDER: S-EPMC3930586 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature