Global changes in gene expression associated with phenotypic switching of wild yeast.

ABSTRACT:

Background

Saccharomyces cerevisiae strains isolated from natural settings form structured biofilm colonies that are equipped with intricate protective mechanisms. These wild strains are able to reprogram themselves with a certain frequency during cultivation in plentiful laboratory conditions. The resulting domesticated strains switch off certain protective mechanisms and form smooth colonies that resemble those of common laboratory strains.

Results

Here, we show that domestication can be reversed when a domesticated strain is challenged by various adverse conditions; the resulting feral strain restores its ability to form structured biofilm colonies. Phenotypic, microscopic and transcriptomic analyses show that phenotypic transition is a complex process that affects variou

SUBMITTER: Stovicek V 

PROVIDER: S-EPMC3930820 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature