CXC chemokines and chemokine receptors in gastric cancer: from basic findings towards therapeutic targeting.

ABSTRACT: Gastric cancer is the fourth most common cancer, and the second-highest cause of cancer-related deaths worldwide. Despite extensive research to identify novel diagnostic and therapeutic agents, patients with advanced gastric cancer suffer from a poor quality of life and poor prognosis, and treatment is dependent mainly on conventional cytotoxic chemotherapy. To improve the quality of life and survival of gastric cancer patients, a better understanding of the underlying molecular pathologies, and their application towards the development of novel targeted therapies, is urgently needed. Chemokines are a group of small proteins associated with cytoskeletal rearrangements, the directional migration of several cell types during development and physiology, and the host immune response via intera

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC3930968 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature