Temporal specification and bilaterality of human neocortical topographic gene expression.

ABSTRACT: Transcriptional events involved in the development of human cerebral neocortex are poorly understood. Here, we analyzed the temporal dynamics and laterality of gene expression in human and macaque monkey neocortex. We found that interareal differences exhibit a temporal hourglass pattern, dividing the human neocortical development into three major phases. The first phase, corresponding to prenatal development, is characterized by the highest number of differential expressed genes among areas and gradient-like expression patterns, including those that are different between human and macaque. The second, preadolescent phase, is characterized by lesser interareal expression differences and by an increased synchronization of areal transcriptomes. During the third phase, from adolescence onward

SUBMITTER: Pletikos M 

PROVIDER: S-EPMC3931000 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature