Combined linkage disequilibrium and linkage mapping: Bayesian multilocus approach.

ABSTRACT: Quantitative trait loci (QTL) affecting the phenotype of interest can be detected using linkage analysis (LA), linkage disequilibrium (LD) mapping or a combination of both (LDLA). The LA approach uses information from recombination events within the observed pedigree and LD mapping from the historical recombinations within the unobserved pedigree. We propose the Bayesian variable selection approach for combined LDLA analysis for single-nucleotide polymorphism (SNP) data. The novel approach uses both sources of information simultaneously as is commonly done in plant and animal genetics, but it makes fewer assumptions about population demography than previous LDLA methods. This differs from approaches in human genetics, where LDLA methods use LA information conditional on LD information or t

SUBMITTER: Pikkuhookana P 

PROVIDER: S-EPMC3931163 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature