The genetic basis and experimental evolution of inbreeding depression in Caenorhabditis elegans.

ABSTRACT: Determining the genetic basis of inbreeding depression is important for understanding the role of selection in the evolution of mixed breeding systems. Here, we investigate how androdioecy (a breeding system characterized by partial selfing and outcrossing) and dioecy (characterized by obligatory outcrossing) influence the experimental evolution of inbreeding depression in Caenorhabditis elegans. We derived inbred lines from ancestral and evolved populations and found that the dioecious lineages underwent more extinction than androdioecious lineages. For both breeding systems, however, there was selection during inbreeding because the diversity patterns of 337 single-nucleotide polymorphisms (SNPs) among surviving inbred lines deviated from neutral expectations. In parallel, we also follow

SUBMITTER: Chelo IM 

PROVIDER: S-EPMC3931175 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature