A comparison between whites and blacks with severe multi-organ iron overload identified in 16,152 autopsies.

ABSTRACT:

Background & aims

Little is known about differences in the prevalence of severe iron overload at death in whites and blacks. We evaluated data and samples from 16,152 autopsies (8484 whites, 7668 blacks) performed at a single university hospital.

Methods

Cases of severe multi-organ iron overload were identified by review of autopsy protocols and Perls-stained tissue specimens, analysis of hepatocyte and Kupffer cell iron levels, and measurement of liver tissue iron concentrations.

Results

We analyzed autopsy data from 10,345 adults (age > or =21 years), 1337 children (1-20 years), and 4470 infants (<1 year). Iron overload without reports of excessive exogenous iron was observed in 18 adults; the prevalence in whites and blacks was 0.0019 and 0.0015, respectively (P =

SUBMITTER: Barton JC 

PROVIDER: S-EPMC3931257 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature